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目的 探讨血清可溶性E 选择素 (sE selectin)浓度与血压水平、肥胖度、血糖及血脂等的关系。方法 测定 95例无靶器官损害的 1级原发性高血压患者 (HT组 )和 35例正常血压者 (NT组 )的空腹血清sE selectin浓度、收缩压 (SBP)、舒张压 (DBP)、体重指数 (BMI)、空腹血糖 (FPG)、总胆固醇 (TC)和三酰甘油 (TG)。分析血清sE selectin浓度与其他各项参数的相关性。结果 ①HT组血清sE selectin浓度为 ( 4 2 .5± 15 .3) μg/L ,高于NT组的 ( 33.2± 14 .8) μg/L(P <0 .0 1) ,但经协方差较正BMI后 ,两组间血清sE selectin浓度的差异无显著性 ;②两组 ( 130例 )的血清sE selectin浓度为 ( 4 0 .0± 15 .7) μg/L ,与SBP、DBP、BMI和TG呈显著正相关(P值分别 <0 .0 5和 <0 .0 0 1) ;③在剔除超重、体重过轻者后 ,HT组 ( 2 9例 )与NT组 ( 30例 )的血清sE selectin浓度分别为 ( 37.5± 12 .3) μg/L和 ( 35 .2± 15 .0 ) μg/L ,两组差异无显著性 ,但仍与BMI显著相关 ,而与血压值不相关。结论 无靶器官损害的 1级原发性高血压患者和正常血压者血清sE selectin浓度与血压不相关 ,而与人体肥胖程度显著相关
Objective To investigate the relationship between serum soluble E-selectin (sE selectin) and blood pressure, obesity, blood glucose and blood lipids. Methods Serum levels of sE selectin, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were determined in 95 patients with primary hypertension without HT and 35 patients with NT (NT) BMI, FPG, TC and TG. Analysis of serum sE selectin concentration and other parameters of the correlation. Results ① The serum concentration of sE selectin in HT group was (42.5 ± 15.3) μg / L, higher than that in NT group (33.2 ± 14.8 μg / L, P <0.01) There was no significant difference in the serum sE selectin concentration between the two groups after correction of BMI. (2) Serum sE selectin concentration was (40.0 ± 15.7) μg / L in two groups (130 cases) There was a significant positive correlation between BMI and TG (P <0.05 and <0.001). ③ After removing overweight and underweight, HT group (29 cases) and NT group (30 cases) (37.5 ± 12.3 μg / L and 35.2 ± 15.0 μg / L, respectively), but there was no significant difference between the two groups, but it was still significantly correlated with BMI, but not with blood pressure Related. Conclusion The serum concentration of sE selectin in patients with primary hypertension and normotensive subjects without target organ damage is not related to blood pressure but significantly correlated with the degree of obesity in the human body