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60～80%的偏头痛患者用心得安治疗效果较好。需注意两点:1.剂量差别较大,每日80mg～240mg。2.均口服给药。血浆浓度相差显著,而与疗效无关。研究对象为女性11例,男性11例,共22例。年龄范围为19-53岁。偏头痛发作持续3年以上,每周至少发作1次,选择对象为以前未服过心得安或未服过用于预防发作的其它药物的病例,其它5例因记录不详未列入本组内。分别服消旋心得安氢氯化物40mg、80mg、120mg、240mg,每日2～3次,连续服药6周,该治疗结束后做血浆心得安与4-羟心得安测定。出现付作用时未再增加剂量,而偏头痛症状减轻了约70%。试验结果表明,在13例中,偏头痛症状减轻70%。每日服40mg 5例,每日服120mg5例,每日
60 to 80% of patients with migraine headache treatment is better. Need to pay attention to two points: 1. Dose differences larger daily 80mg ~ 240mg. 2. Oral administration. Significant difference in plasma concentrations, but not with the efficacy. The study object was 11 females and 11 males, a total of 22 cases. The age range is 19-53 years old. Migraine attacks lasts more than 3 years, at least 1 episode per week. Patients who have not received propranolol or have not taken any other drugs for preventing seizures have been selected. The remaining 5 cases were not included in this group due to unknown records . Respectively anti-cyclothrine hydrochloride Anhydride 40mg, 80mg, 120mg, 240mg, 2 to 3 times daily for 6 weeks, after the treatment of plasma propranolol and 4-hydroxy propranolol determination. There was no additional dose at the time of treatment, and migraine symptoms were reduced by about 70%. Test results show that in 13 cases, migraine symptoms reduced by 70%. Daily serving 40mg 5 cases, daily serving 120mg 5 cases, daily