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染色体因种种环境因素而发生改变。本文例举苯,氯乙烯单体,苯乙烯和重金属化合物职业接触和实验研究的染色体异常的产生机理,同时对工业医学和细胞遗传学的关系加以探讨。一、职业性接触诱发的染色体异常 1.苯Vigliani等人1964年报告了苯操作工的白血病发病率竟比一般人高出20倍。Tough等追踪了20名接触苯1～20年的操作工,并做了染色体分析,发现染色体断裂数比
Chromosomes change due to various environmental factors. This article illustrates the mechanism of chromosomal abnormalities in occupational contact and experimental studies of benzene, vinyl chloride monomer, styrene and heavy metal compounds, and discusses the relationship between industrial medicine and cytogenetics. First, occupational exposure-induced chromosomal abnormalities 1. Benzene Vigliani et al reported in 1964 benzene workers the incidence of leukemia was 20 times higher than the average person. Tough and other tracked 20 workers exposed to benzene 1 to 20 years and did a chromosome analysis and found that the number of chromosome rupture ratio