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缺氧诱导因子-1(HIF-1)是缺氧条件下广泛存在于哺乳动物和人体内的一种核转录因子,是介导细胞对缺氧微环境进行适应性反应的关键性转录调控基因。HIF-1通过与靶基因缺氧反应元件(HRE)结合,促进其转录,引起一系列细胞对缺氧的反应。作为HIF-1最主要靶基因之一的血管内皮生长因子(VEGF),是目前所知作用最强的一种促血管生长因子。已知二者在皮肤鳞状细胞癌(SCC)及基底细胞癌(BCC)的多种恶性肿瘤中均有高表达,且表达呈正相关。HIF-lα和VEGF的联合表达在皮肤SCC和BCC的发生、发展中作用的研究,可能为皮肤SCC及BCC预后的判断和利用以HIF-1α和VEGF为靶点的基因生物治疗提供新的途径。
Hypoxia-inducible factor-1 (HIF-1) is a nuclear transcription factor widely present in mammals and humans under hypoxia and is a key transcriptional regulatory gene that mediates the adaptive response of cells to hypoxic microenvironment . HIF-1 through the target gene hypoxia response element (HRE) to promote its transcription, causing a series of cells to hypoxia response. Vascular endothelial growth factor (VEGF), one of the most important target genes of HIF-1, is the most potent pro-angiogenic factor known to date. It is known that both are highly expressed in many malignant tumors of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), and the expression is positively correlated. The study of the role of HIF-1α and VEGF in the occurrence and development of cutaneous SCC and BCC may provide a new way to judge the prognosis of cutaneous SCC and BCC and to utilize the biological therapy of HIF-1α and VEGF .