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目的:比较氯解磷定微泵与肌注二种不同的给药方式在救治急性有机磷中毒中的治疗效果。方法:将42例急性有机磷农药中毒患者在常规对抗毒蕈碱样症状治疗基础上按就诊顺序单号和双号分为观察组和对照组各21例,观察组采用微泵注入氯解磷定的方式,对照组应用肌注氯解磷定的方式,比较两组患者的治疗效果和胆碱酯酶(ChE)的恢复情况。结果:观察组中胆碱酯酶的恢复时间、氯解磷定的总量、从昏迷到清醒时间和住院的平均时间均明显小于对照组(P<0.05)。结论:微泵注入氯解磷定治疗急性有机磷中毒的效果明显优于肌注氯解磷定。
OBJECTIVE: To compare the therapeutic effects of two different modes of administration of PCP and intramuscular injection in the treatment of acute organophosphate poisoning. Methods: Forty-two patients with acute organophosphorus pesticide poisoning were divided into the observation group and the control group according to the treatment order single number and double number on the basis of routine treatment against muscarinic symptoms. The observation group was treated with micro-pump The way, the control group, intramuscular injection of chlorophyll a method to compare the treatment effect of two groups of patients and the recovery of cholinesterase (ChE). Results: The recovery time of cholinesterase and the total amount of chlorophenols in the observation group were significantly shorter than those in the control group from the coma to awake time and hospitalization (P <0.05). Conclusion: The effect of micro-pump injection of chlorpheniramine for the treatment of acute organophosphate poisoning is obviously superior to intramuscular injection of chlorophyll-phosphorylation.