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1963年,Reye、Morgan和Barel报告21例儿童脂变性脑病,首次将脑病和内脏脂肪变性联系在一起,作为一种临床病理实体来研究,引起广泛注意。迄今,国外报导已不下千余例,国内约200例。本病的临床特点是前驱病毒感染后出现剧烈呕吐,继以昏迷、惊厥脑症状,肝脏肿大,血氨升高,血糖降低,血清谷草转氨酶(SGOT)和谷丙转氨酶(SGPT)活度增
In 1963, Reye, Morgan and Barel reported 21 cases of childhood fatty degeneration encephalopathy, for the first time encephalopathy and visceral steatosis associated, as a clinical pathological entity to study, causing widespread attention. So far, no fewer than a thousand cases have been reported in foreign countries and about 200 in China. The clinical features of this disease are severe vomiting after infection with the precursor virus, followed by coma, convulsive brain symptoms, enlarged liver, increased blood ammonia, decreased blood glucose, increased activity of serum aspartate aminotransferase (SGOT) and alanine aminotransferase (SGPT)