论文部分内容阅读
目的:研究肺癌患者血清血清人转移生长因子β1(TGF-β1)水平变化及其与临床特征的关系。方法:选择自2014年2月至2015年10月在医院接受诊治的肺癌患者56例为观察组,另选同期在医院接受健康体检的人员55例作为对照组,对比两组血清TGF-β1水平,分析血清TGF-β1水平与临床特征的关系。结果:观察组的血清TGF-β1水平(65825.24±23152.66)pg/ml,显著高于对照组的(48792.56±15247.39)pg/ml,差异存在统计学意义(t=4.569,P=0.000);血清TGF-β1水平与不同性别、年龄、病理类型及是否手术无关,差异不存在统计学意义(P>0.05),观察组≥Ⅲ期患者的血清TGF-β1水平显著高于≤Ⅱ期的水平,且有淋巴结转移患者显著高于无转移者,差异存在统计学意义(P<0.05)。结论:肺癌患者血清TGF-β1水平较健康人体更高,且其与患者的临床分期及肿瘤淋巴结转移均呈正相关。
Objective: To study the changes of serum level of transforming growth factor-β1 (TGF-β1) in serum of patients with lung cancer and its relationship with clinical features. Methods: From February 2014 to October 2015, 56 patients with lung cancer undergoing diagnosis and treatment in the hospital were selected as the observation group and 55 healthy people were selected as the control group during the same period. The serum levels of TGF-β1 were compared between the two groups , The relationship between serum TGF-β1 level and clinical features was analyzed. Results: The serum level of TGF-β1 (65825.24 ± 23152.66) pg / ml in the observation group was significantly higher than that of the control group (48792.56 ± 15247.39) pg / ml, the difference was statistically significant (t = 4.569, P = 0.000) The level of TGF-β1 in patients with stage Ⅲ disease was significantly higher than that of stage Ⅱ without significant difference in gender, age, pathological type and whether the surgery, the difference was not statistically significant (P> 0.05) The patients with lymph node metastasis were significantly higher than those without metastasis, the difference was statistically significant (P <0.05). Conclusion: The serum level of TGF-β1 in patients with lung cancer is higher than that in healthy people, and it is positively correlated with the clinical stage and tumor lymph node metastasis.