用广州管圆线虫感染期幼虫感染大白鼠，获得成功。观察结果显示，感染后23～32天病死的大白鼠队脑部病变最为严重，这是由于幼龄成虫从脑向肺转移时损伤和刺激血管壁，引起脑出血，加上虫体对脑组织的直接损伤所致。40～68天病死的大白鼠，主要病变在肺部，此期由于虫卵的刺激和幼虫移行过程中造成的损伤，使肺组织受到破坏，肺部病变广泛时可引起呼吸衰竭。一般情况下鼠体内寄生的虫数越多，死亡时间越早。 Obtain infection with larvae of C. elegans in rats. Observations show that 23 to 32 days after infection died of brain disease in rats most severe brain disease, which is due to young adults from brain to lung metastasis damage and stimulate the vessel wall, causing cerebral hemorrhage, coupled with parasites on brain tissue Caused by direct damage. 40 to 68 days dead rats, the main lesion in the lungs, the period due to the stimulation of eggs and larvae caused by the migration process of damage to the lung tissue is damaged, extensive lung disease can cause respiratory failure. Under normal circumstances, the more parasites in the mouse body, the earlier the death.