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为明确中国上海地区小儿特发性肾病综合征与HLA的相关状况,运用经典的微量淋巴细胞毒试方法进行研究,发现HLA-DR_7,在激素敏感型肾病病人中显著性增高,频复发与OR_9相关,激素耐药型与DR_4相关。用聚合酶链反应(PCR)/顺序特异的寡核苷酸(SSO)探针方法进行基因分型,发现HLA-DRB1＊07与激素敏感型相关,DRB1＊09与频复发相关。以上结果在国内领先,填补了国内空白。特发性肾
In order to clarify the related status of idiopathic nephrotic syndrome in children with HLA in Shanghai area of China, the classical method of micro-lymphocyte cytotoxicity was used to study HLA-DR-7 in patients with hormone-sensitive nephropathy. The frequency recurrence and OR_9 Related, hormone-resistant and DR_4-related. Genotyping was performed using polymerase chain reaction (PCR) / sequence-specific oligonucleotide (SSO) probe methodology and found that HLA-DRB1 * 07 is associated with hormone-sensitive DRD1 * 09 associated with frequency recurrence. These results lead in the country, to fill the gaps in the country. Idiopathic kidney