尿毒症患者机体免疫力低,易并发各种感染,感染性发热是其住院的常见原因~([1])。头孢菌素因抗菌谱广、组织穿透力强、肾毒性小等优点在临床上被广泛应用于尿毒症患者。尿毒症患者因肾功能衰竭,代谢和清除排泄能力明显降低等因素导致药物蓄积易引起头孢菌素脑病,严重者可并发癫癎大发作,甚至危及生命。本文通过探讨其临床特点、发病机制及治疗措施,为尿毒症患者的抗生素合理运用提供参考。1资料与方法 Uremic patients with low immunity, easy to complicated by various infections, infectious fever is a common cause of hospitalization ~ ([1]). Cephalosporin due to broad antibacterial spectrum, strong tissue penetration, small renal toxicity and other advantages in clinical widely used in uremic patients. Uremic patients due to renal failure, metabolism and clearance of significantly reduced excretion and other factors lead to drug accumulation easily lead to cephalosporin encephalopathy, severe cases may be complicated by epileptic seizures, and even life-threatening. In this paper, by exploring its clinical features, pathogenesis and treatment measures for the rational use of antibiotics in patients with uremia provide a reference. 1 data and methods