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2-甲基吡啶与碘甲烷反应生成碘化1,2-二甲基吡啶铭(3);后者与邻硝基苯甲醛反应得碘化1-甲基-2-(邻硝基苯乙烯基)吡啶鎓(4);然后经催化氢化生成1-甲基-2-[2-(邻氨基苯)乙基]哌啶(2);再与对甲氧基苯甲酰氯反应,形成恩卡胺盐基,四步总收率约40%。
The reaction of 2-picoline and methyl iodide to form 1,2-dimethylpyridinium iodide (3); the latter reaction with o-nitrobenzaldehyde iodized 1-methyl-2- (o-nitrostyrene Yl) pyridinium (4); followed by catalytic hydrogenation to give 1-methyl-2- [2- (o-aminophenyl) ethyl] piperidine (2) Cardamine base, four-step total yield of about 40%.