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旋光性氨基酸或其酯室温下在NaHTe/EtOH和NaHTe/H_2O体系中与羰基化合物反应,一步得到N-烷基化氨基酸或其酯。具有二级胺基的脯氨酸苄酯亦能高产率生成N-Bzl-L-Pro·OEt。反应条件温和,不发生外消旋化,适用于带有各种基团的氨基酸。
The optically active amino acids or their esters are reacted with carbonyl compounds at room temperature in NaHTe / EtOH and NaHTe / H 2 O systems to give the N-alkylated amino acids or esters thereof in one step. N-Bzl-L-Pro · OEt can also be produced with high yield from proline benzyl ester with secondary amine group. The reaction conditions are mild and do not occur racemization, suitable for amino acids with various groups.