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目的：探讨ｃｙｃｌｉｎＥ蛋白表达与肠型胃癌的临床病理特征及预后的关系。方法：以免疫组化法分析５９例肠型胃癌的ｃｙｃｌｉｎＥ蛋白表达情况。结果：正常胃粘膜上皮细胞呈阴性反应，而３０例（３０／５９）肠型胃癌组织被免疫染色。ｃｙｃｌｉｎＥ的异常表达与肿瘤的浸润深度显著相关，强阳性者５年生存率低。结论：ｃｙｃｌｉｎＥ的异常表达与肠型胃癌的发展有关，并可作为一项预后指标
Objective: To investigate the relationship between cyclinE protein expression and the clinicopathological features and prognosis of intestinal type gastric cancer. Methods: The expression of cyclinE protein in 59 cases of intestinal type gastric carcinoma was analyzed by immunohistochemistry. RESULTS: Normal gastric mucosal epithelial cells showed a negative reaction, while 30 cases (30/59) of intestinal type gastric cancer tissues were immunostained. The abnormal expression of cyclinE was significantly associated with the depth of tumor invasion, and the 5-year survival rate of strongly positive patients was low. Conclusion: The abnormal expression of cyclinE is related to the development of intestinal type gastric cancer and can be used as a prognostic indicator.