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按双盲法对46例幽门螺旋杆菌(HP)阳性慢性胃炎患者随机给予呋喃唑酮100mg,每日3次;或安慰剂,疗程1个月.治疗前后各经胃镜检查1次.详细记录症状变化.结果:呋喃唑酮对HP的清除率为54.2%,HP 清除者胃粘膜炎症明显改善,而安慰剂组的HP 和炎症均无明显变化;呋喃唑酮组的症状改善比安慰剂组明显.HP 清除或明显减少者的症状改善比HP 无明显变化者明显;临床症状的改善与胃粘膜炎症程度的变化无明显关系,但与活动性炎症的消退有关.
46 patients with Helicobacter pylori (HP) -positive chronic gastritis were randomly assigned to receive 100 mg of furazolidone three times a day or placebo for 1 month by double-blind method, and gastroscopy was performed before and after treatment, and the symptoms were recorded in detail. Results: The clearance rate of furazolidone to HP was 54.2%, the gastric mucosal inflammation of HP-scavenger was significantly improved, while no significant changes were found in HP and inflammation in the placebo group, while the symptoms in the furazolidone group were more obvious than those in the placebo group The improvement of symptoms was not obvious when compared with that of HP. The improvement of clinical symptoms was not related to the changes of gastric mucosal inflammation, but was related to the regression of active inflammation.