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目的探讨VEGF与卵巢上皮性癌组织类型和临床预后的关系。方法用免疫组织化学方法检测VEGF在79例人卵巢上皮性癌组织中的表达,分析VEGF与卵巢上皮性癌组织学分类、临床分期、腹水、淋巴结转移、预后的关系。结果在79例卵巢上皮性癌中50例(63.3%)VEGF表达阳性。在晚期卵巢癌(P<0.01)、大量腹水(P<0.05)和腹水细胞学阳性(P<0.05)者中VEGF表达阳性率显著增高。结论VEGF在卵巢癌的发展和腹水形成中起着重要作用。检测肿瘤中VEGF的表达有助于了解卵巢癌的生物学特性,为患者提供预后信息。
Objective To investigate the relationship between VEGF and ovarian epithelial carcinoma tissue type and clinical prognosis. Methods Immunohistochemistry was used to detect the expression of VEGF in 79 cases of human epithelial ovarian cancer. The relationship between VEGF and the histological classification, clinical stage, ascites, lymph node metastasis and prognosis of ovarian epithelial carcinoma was analyzed. Results The positive expression of VEGF in 50 cases (63.3%) of 79 cases of epithelial ovarian cancer. The positive rate of VEGF expression in advanced ovarian cancer (P <0.01), large amount of ascites (P <0.05) and ascites cytology (P <0.05) were significantly higher. Conclusion VEGF plays an important role in the development of ovarian cancer and in the formation of ascites. Detecting the expression of VEGF in tumors helps to understand the biological characteristics of ovarian cancer and provide prognostic information to patients.