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1972年,Addison氏首先运用敏感的免疫放射法检测血清铁蛋白(SF)。1974年,Miles等人将夹心免疫放射法用于SF测定。Carddiff并观察到SF与贮铁密切相关,遂引起临床关注。近年来,发现许多非铁负荷过多疾病(肿瘤、肝病及类风湿关节炎等)都可使SF增高,而血清铁、转铁蛋白饱和度或骨髓活检铁染色却显示铁缺乏或正常,这促使了对铁蛋白的研究更加深入。一、铁蛋白的异构谱,铁蛋白的分子量约为45万道尔顿,由24个亚单位组成,呈均
In 1972, Addison first detected serum ferritin (SF) using a sensitive immunoradiometric assay. Miles et al. Used sandwich immunoradiography for SF determination in 1974. Carddiff and observed SF and iron closely related, then cause clinical concern. In recent years, many non-iron overload diseases (tumor, liver disease and rheumatoid arthritis, etc.) have been found to increase SF, while serum iron, transferrin saturation or bone marrow biopsy iron staining shows iron deficiency or normal Promote the study of ferritin more in-depth. First, ferritin isomerism, ferritin molecular weight of about 450,000 Daltons, composed of 24 subunits, were average