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目的探讨不规则抗体检测及IgG抗-A(B)血型抗体效价在多次妊娠史孕妇产前检查中的意义。方法以2015年12月至2016年11月孕期监测的2 020例孕妇为研究对象,均接受不规则抗体检测、O型孕妇产前IgG抗-A(B)抗体效价检测,统计首次妊娠孕妇与多次妊娠史孕妇的数据,对2组的不规则抗体检测阳性率和O型孕妇产前IgG抗-A(B)效价1∶64及以上阳性率进行对比。结果首次妊娠与2次及以上妊娠的不规则抗体发生频率比较,差异有统计学意义(P<0.05);首次妊娠与2次及以上妊娠的IgG抗-A(B)抗体效价1∶64及以上比较,差异有统计学意义(P<0.05);429名O型孕妇血清IgG抗-A(B)抗体效价随着妊娠次数的增多,抗体效价水平也不断增高。结论检测不规则抗体及O型孕妇血清的IgG抗-A(B)抗体在多次妊娠孕妇产前检查中有重要意义,有利于新生儿溶血病的早期诊断和预防性治疗。
Objective To investigate the significance of irregular antibody test and IgG anti-A (B) blood group antibody titer in prenatal examination of pregnant women with multiple pregnancy history. Methods A total of 2,020 pregnant women monitored during pregnancy from December 2015 to November 2016 were enrolled in this study. All of them were tested for irregular antibodies and prenatal IgG anti-A (B) antibody titer in O-pregnant women. The first-time pregnant women And pregnant women with multiple pregnancy history data, the two groups of irregular antibody test positive rate and type O pregnant women prenatal IgG anti-A (B) titer 1:64 and positive rates were compared. Results There was significant difference in the frequency of irregular antibodies between the first pregnancy and the second and the third trimester of pregnancy (P <0.05). The titer of IgG anti-A (B) antibody in the first trimester and second trimester pregnancy was 1:64 (P <0.05). The titer of IgG anti-A (B) antibody in 429 O-pregnant women increased with the number of pregnancy and the titer of antibody increased. Conclusion The detection of IgG anti-A (B) antibody in serums of irregular antibodies and O-type pregnant women is of great significance in the prenatal examination of pregnant women with multiple pregnancies, which is good for the early diagnosis and prophylactic treatment of hemolytic disease in newborn.