Because functional magnetic resonance imaging can be used for dynamic observation of functional cortical changes after brain injuries,we followed up functional magnetic resonance imaging manifestations of a language-related brain network in a low-grade glioma patient.Disease progression and therapy during a 3-year period were followed up at different time points:before and after reoperation,after radiation therapy,and 1 year after irradiation.During the whole 3-year follow-up period,the patient exhibited no neurological deficits while functional magnetic resonance imaging revealed different topologies of the language-related brain network.During disease progression and after irradiation,the language-related brain network was extended or completely transferred to the nondominant (right) hemisphere.In addition,after reoperation and 1 year after irradiation,language areas were primarily found in the language dominant (left) hemisphere.Our results suggest a high level of adaptability of the language-related cortical network of the bilateral hemispheres in this low-grade glioma patient. Because functional magnetic resonance imaging can be used for dynamic observation of functional cortical changes after brain injuries, we followed up functional magnetic resonance imaging manifestations of a language-related brain network in a low-grade glioma patient. Disease progression and therapy during a 3- year period were followed up at different time points: before and after reoperation, after radiation therapy, and 1 year after irradiation. During the whole 3-year follow-up period, the patient showed no neurological deficits while functional magnetic resonance imaging revealed different topologies of the language-related brain network. Disease progression and after irradiation, the language-related brain network was extended or completely transferred to the nondominant (right) hemisphere. In addition, after reoperation and 1 year after irradiation, language areas previously also found in the language dominant (left) hemisphere.Our results suggest a high level of adaptability of th e language-related cortical network of the bilateral hemispheres in this low-grade glioma patient.