Objective:To observe the clinical effects of acupuncture for diabetic peripheral neuropathy. Methods: Totally 65 patients were randomly divided into a treatment group of 32 cases and a control group of 33 cases. On the basis of conventional treatment of diabetes, acupuncture was used in the treatment group, and inositol was orally administered in the control group. During a 3-month treatment, changes in the symptoms were observed. Results: In the treatment group, 16 cases were markedly relieved, 12 cases improved, and 4 cases failed, with a total effective rate of 87.5%. In the control group, 7 cases were markedly relieved, 14 cases improved and 12 cases failed, with a total effective rate of 63.6%. There was a significant difference in the total effective rate between the 2 groups (P<0.05). Conclusion: Acupuncture may show good effects for diabetic peripheral neuropathy.