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目的 探讨淋系分化抗原在急性髓性细胞白血病及髓系分化抗原在急性淋巴细胞白血病的表达及疗效。方法 采用流式细胞术检测 70例急性白血病的免疫表型 ,其中急性髓细胞白血病 32例 ,急性淋巴细胞白血病 38例。 32例急性髓细胞白血病有 9例除表达髓系抗原外 ,尚有淋巴抗原表达。 38例急性淋巴细胞白血病有 11例除表达淋系抗原外 ,尚有髓系抗原表达。结果 9例LY+ AmL病人用常规DA方案化疗仅 1例缓解 ,11例MY+ ALL病人用标准DVP方案化疗无一缓解。LY+ AmL的病人改用DOAP方案化疗 ,有 2例获缓解 ,缓解率 2 5 %。MY+ ALL改用QOAP方案化疗有 2例获缓解 ,1例获部分缓解 ,缓解率 18.1% ,有效率 2 7.2 %。结论 对于LY+ AmL及MY+ ALL病人其化疗方案的选择应AML与ALL两者兼顾方可提高缓解率。
Objective To investigate the expression and therapeutic effect of lymphoid differentiation antigen on acute myeloid leukemia and myeloid differentiation antigen in acute lymphoblastic leukemia. Methods The immunophenotypes of 70 cases of acute leukemia were detected by flow cytometry, including 32 cases of acute myeloid leukemia and 38 cases of acute lymphoblastic leukemia. In 32 cases of acute myeloid leukemia, 9 cases expressed myeloid antigens besides lymphoid antigen. In 38 cases of acute lymphoblastic leukemia, 11 cases expressed myeloid antigens in addition to lymphoid antigens. Results Of the 9 patients with LY + AmL, only 1 patient was relieved by conventional DA regimen and 11 patients with MY + ALL had no response by standard DVP regimen. LY + AmL patients switched to DOAP chemotherapy, 2 patients were relieved, the response rate of 25%. Two of the patients with MY + ALL who switched to QOAP regimen were relieved. One patient was partially relieved, with a response rate of 18.1% and an effective rate of 7.22%. Conclusion The choice of chemotherapy regimen for patients with LY + AmL and MY + ALL should be both AML and ALL to improve remission rate.