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目的:验证复方冬菊对上皮性癌发生促癌阶段的抑制作用。方法:30只ICR小鼠随机分为3组,模型组、阳性药物对照组和复方冬菊组。给药组小鼠分别连续灌胃干预药物6d,末次给药后将致炎剂涂抹于3组实验小鼠一侧耳廓,5h后处死动物,用打孔器取两侧耳片,比较给药组与模型组耳肿胀程度。结果:复方冬菊组和模型组之间小鼠耳片重量差值有显著性差异(p<0.05),复方冬菊组与阳性对照组之间无显著性差异。结论:复方冬菊在上皮性癌发生的促癌阶段有一定的预防作用。
OBJECTIVE: To verify the inhibitory effect of Fufang Dongju on the carcinogenesis of epithelial carcinoma. Methods: Thirty ICR mice were randomly divided into 3 groups: model group, positive drug control group and compound Dongju group. The mice in the drug-administered group were continuously administered with drugs for 6 days. After the last administration, the inflammatory agents were applied to the auricles of one of the three groups of experimental mice. After 5 hours, the animals were sacrificed and the bilateral ear pieces were removed with a puncher. The degree of ear swelling with the model group. RESULTS: There was a significant difference in the weight of the mouse ear between the compound Dongju group and the model group (p<0.05). There was no significant difference between the compound Dongju group and the positive control group. Conclusion: Compound winter chrysanthemum has a certain preventive effect in the promotion stage of epithelial cancer.