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目的 :探讨细胞粘着分子 CD44 V6 在膀胱肿瘤中的作用及其临床意义。方法 :利用免疫荧光法检测了2 8例膀胱肿瘤和 5例正常膀胱移行上皮组织中 CD44 V6 的表达情况。结果 :浸润型膀胱肿瘤组织 CD44 V6 阳性表达率为 44 .44 %和 75 .0 0 % ,浅表型膀胱肿瘤阳性表达率为 13.33% (P <0 .0 5 ) ,正常组织均阴性表达。半定量检测分析显示 CD44 V6 的表达水平与肿瘤的分级和分期相关。结论 :CD44 V6 的检测是一种提示肿瘤浸润和预后有实用价值的诊断指标。
Objective: To investigate the role of cell adhesion molecule CD44 V6 in bladder tumor and its clinical significance. Methods: Immunofluorescence was used to detect the expression of CD44 V6 in 28 cases of bladder tumor and 5 cases of normal bladder transitional epithelium. Results: The positive rate of CD44 V6 in invasive bladder tumor was 44.44% and 75.0% respectively. The positive rate of superficial bladder tumor was 13.33% (P <0.05). The positive rate of CD44 V6 in invasive bladder tumor was negative. Semi-quantitative analysis showed that the expression of CD44 V6 correlated with tumor grade and stage. Conclusion: The detection of CD44 V6 is a diagnostic indicator of tumor invasion and prognosis.