论文部分内容阅读
目的探讨血清抗血管紧张素II 1型和α1肾上腺素能受体抗体与老年T2DM合并冠心病(CAD)患者死亡危险性的关系。方法选取老年T2DM患者234例,根据是否合并CAD平均分为T2DM合并冠心病(T2DM+CAD)组和单纯糖尿病(T2DM)组,进行追踪研究3~11年。以合成的α1R和AT1R多肽片段为抗原,应用酶联免疫吸附法检测上述患者血清中抗α1R和AT1R自身抗体。结果(1)T2DM+CAD组AT1R和α1R抗体阳性率高于T2DM组(48.7%vs 20.5%,36.8%vs 21.4%,P<0.01);(2)T2DM+CAD组抗α1R和AT1R抗体受体阳性组死亡率高于受体抗体阴性组(47.4%vs10.0%,P<0.01);(3)α1R和AT1R抗体阳性组(指同一个体α1R和AT1R均阳性)死亡率高于单抗体阳性组(指同一个体仅α1R或AT1R阳性)(37.2%vs 11.6%vs 12.3%,P<0.01)。结论α1R和AT1R抗体阳性与老年T2DM合并CAD患者死亡的危险性增高有关,双抗体阳性是老年T2DM合并CAD患者死亡的危险因素。
Objective To investigate the relationship between serum anti-angiotensin II type 1 and α1 adrenergic receptor antibodies and risk of death in elderly patients with T2DM and coronary heart disease (CAD). Methods A total of 234 elderly patients with T2DM were selected and followed up for 3 to 11 years according to whether they were divided into two groups: T2DM + CAD group and T2DM group. Anti-α1R and AT1R autoantibodies were detected by enzyme-linked immunosorbent assay (ELISA) using the synthesized α1R and AT1R polypeptide fragments as antigens. Results (1) The positive rates of AT1R and α1R in T2DM + CAD group were higher than those in T2DM group (48.7% vs 20.5%, 36.8% vs 21.4%, P <0.01) (3) The mortality rate of α1R and AT1R positive group (positive for both α1R and AT1R in the same individual) was higher than that of the single antibody (47.4% vs10.0%, P <0.01) Group (means that the same individual is only α1R or AT1R positive) (37.2% vs 11.6% vs 12.3%, P <0.01). Conclusion The positive of α1R and AT1R antibodies are related to the increased risk of death in T2DM patients with CAD. The positive of diabodies is the risk factor of death in T2DM patients with CAD.