论文部分内容阅读
血卟啉(HP)和血卟啉衍生物(HPD)用于光敏——激光疗法治疗肿瘤,为肿瘤的早期诊断和治疗开辟了新的途径,已引起国内外医药界的广泛重视。目前,有关HPD光敏作用的分子机制已有报道,单线态氧机制的假说得到了多数学者的公认。但是,近年来的研究表明,HPD的光敏作用可能存在两个途径,单线态氧机制和自由基机制,任何一种都与羟基自由基的生成有
Hematoporphyrin (HP) and hematoporphyrin derivative (HPD) are used for photosensitizing-laser therapy to treat tumors, which has opened up new avenues for the early diagnosis and treatment of tumors and has attracted extensive attention from the medical community at home and abroad. At present, the molecular mechanism of HPD photosensitivity has been reported. The hypothesis of singlet oxygen mechanism has been recognized by most scholars. However, recent studies have shown that there may be two approaches to the photosensitizing effect of HPD, singlet oxygen mechanism and free radical mechanism, and any one is related to the generation of hydroxyl radicals.