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[目的]探讨影响非小细胞肺癌(NSCLC)预后的分子生物学因素。[方法]采用免疫组织化学染色,检测42例NSCIC组织中MMP-2、TIMP-2、NOS(1,2,3)、VEGF、CD44v6、CEA、COX-2、VEGF-C、VEGFR-3等分子生物学指标的表达情况。采用COX比例风险模型进行单因素和多因索回归分析。[结果]全组1年生存率为79%(33/42),2年生存率为50%(21/42),3年生存率为36%(15/42),4年生存率为17%(7/42),5年生存率为10%(4/42)。单因索显示:MMP-2、TIMP- 2、VEGF、COX-2、VEGF-C、VEGFR-3与NSCLC预后显著相关(P<0.05)。COX多因素回归分析显示,TIMP-2、VEGF和VEGFR-3是影响NSCLC预后的重要因素,可以作为判断预后的独立指标(P<0.05)。[结论] TIMP-2、VEGF和VEGFR-3是影响NSCLC术后预后的独立因素。
[Objective] To investigate the molecular biological factors affecting the prognosis of non-small cell lung cancer (NSCLC). [Methods] The expressions of MMP-2, TIMP-2, NOS (1, 2, 3), VEGF, CD44v6, CEA, COX-2, VEGF-C and VEGFR-3 in 42 NSCLC tissues were detected by immunohistochemical staining Molecular biology indicators of the situation. Single-factor and multiple-factor regression analyzes were performed using the COX proportional hazards model. [Results] The overall 1-year survival rate was 79% (33/42), the 2-year survival rate was 50% (21/42), the 3-year survival rate was 36% (15/42) and the 4-year survival rate was 17 % (7/42), 5-year survival rate was 10% (4/42). Single-factor analysis showed that MMP-2, TIMP-2, VEGF, COX-2, VEGF-C and VEGFR-3 were significantly associated with the prognosis of NSCLC (P <0.05). COX multivariate regression analysis showed that TIMP-2, VEGF and VEGFR-3 were important prognostic factors in NSCLC and could be used as independent prognostic indicators (P <0.05). [Conclusion] TIMP-2, VEGF and VEGFR-3 are independent prognostic factors in NSCLC.