脑水肿是神经科危重患者常见的一种病变,也是脑血管病、颅内占位性病变、颅脑损伤和炎症等过程的主要病理生理改变[1-2]。在职业卫生领域,一些化学物质中毒可以导致接触人群脑水肿的发生,如有机溶剂1,2-二氯乙烷、苯的化合物、铅和铊等重金属等,因此建立脑水肿动物模型对研究职业性有害因素所致中毒的发病机制和探索相应的治疗方法和预防控 Brain edema is a common neurological crisis in patients with a disease, but also cerebrovascular disease, intracranial space-occupying lesions, brain injury and inflammation of the main pathophysiological changes [1-2]. In the field of occupational health, some chemical poisoning can lead to cerebral edema in contact with people, such as organic solvents such as 1,2-dichloroethane, benzene compounds, heavy metals such as lead and thallium, etc. Therefore, establishing animal models of brain edema for the study of occupational Sexual harmful elements caused by the pathogenesis of poisoning and explore the appropriate treatment and prevention and control