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目的 研究染料木黄酮对去势大鼠股骨远端形态计量学参数的影响 ,为染料木黄酮防治骨质疏松提供理论依据。方法 雌性Wistar大鼠 4 7只 ,按体重随机分为 6组 :假手术组、去势对照组、去势 +雌激素组 (2 0 μg/kg体重 )、去势 +染料木黄酮组 (染料木黄桐剂量分别为 2 5、5 0、10 0mg/kg体重 )。饲养 3个月后处死 ,测定股骨形态计量学参数。结果 去势组与假手术组比较 ,骨小梁体积、平均骨小梁板密度和厚度减少 ,平均骨小梁板间隙和类骨质宽度增加 ,矿化延迟时间和类骨质成熟时间延长 ,且差异均具有显著性 (P <0. 0 5 )。染料木黄酮各组与去势组比较 ,骨小梁体积和平均骨小梁板厚度增加 ,平均骨小梁板间隙变窄 ,矿化延迟时间和类骨质成熟时间缩短 ,且差异均有显著性 (P <0 . 0 5 )。结论 染料木黄酮有促进骨形成 ,减少切除卵巢后骨量丢失的作用。
Objective To study the effect of genistein on distal femur morphometry in ovariectomized rats and to provide a theoretical basis for the prevention and treatment of osteoporosis by genistein. Methods Forty-seven female Wistar rats were randomly divided into 6 groups according to body weight: sham operation group, castration control group, castrate + estrogen group (20 μg / kg body weight), castrated + genistein group Wood yellow Tong dose of 25,5 0,10 0 mg / kg body weight). After 3 months of sacrifice, femur morphometry parameters were measured. Results Compared with the sham operation group, the trabecular bone volume, average trabecular plate density and thickness decreased, the average trabecular plate gap and osteoid width increased, the mineralization delay time and osteoid maturation time prolonged, And the differences were significant (P <0. 05). In genistein group, the trabecular bone volume and mean trabecular plate thickness increased, the average trabecular plate gap became narrower, the mineralization delay time and osteoid maturation time were shorter than those in the castrated group, and the differences were significant Sex (P <0.05). Conclusion Genistein can promote bone formation and reduce bone loss after ovariectomy.