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低亲和力IgG 受体,即CD16(FcrRⅢ),几乎在所有外周血NK 细胞中得到表达,而CD3~-、CD16~-、CD56~+的NK 细胞小亚群在外周血淋巴细胞中含量低于1%,当用IL-2进行体内治疗时,这类亚群扩增明显。作者为了进一步分析CD16~-这类亚群的细胞功能。首先得到了一系列NK 克隆,对其中一个克隆(TNKZ)进行了研究,它表现出大颗粒淋巴细胞形态,且有正常的NK 活性,由于这个克隆缺少CD16的表达,因而不执行ADCC 作用,CD16的McAb 对NK 依赖的靶细胞不产生细胞毒活性。这些
The low-affinity IgG receptor, CD16 (FcRRⅢ), was expressed in almost all peripheral blood NK cells, while the small subpopulation of CD3 ~ -, CD16 ~ - and CD56 ~ + NK cells in peripheral blood lymphocytes was lower than 1%, when using IL-2 for in vivo treatment, such subpopulations were significantly expanded. In order to further analyze the cellular function of CD16 ~ - subsets. First of all, a series of NK clones were obtained and one of the clones (TNKZ) was studied. It showed large granule lymphocyte morphology with normal NK activity. Since this clone lacks the expression of CD16, it does not perform ADCC and CD16 McAbs do not produce cytotoxic activity on NK-dependent target cells. These ones