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目的:探讨寻常型银屑病(PV)患者外周血单个核细胞(PBMCs)微小RNA-26a(miR-26a)、Toll样受体(TLR)表达情况，分析其与疾病活动的关系。方法:选取2016年6月至2018年6月期间本院就诊的PV患者200例为观察组，依据PASI评分将其分为轻度组71例，中度组84例，重度组45例，选取同时期体检中心健康者100例为对照组。利用荧光定量PCR技术检测PBMCs中miR-26a、TLR2、TLR4 mRNA水平，免疫透射比浊法检测血清CRP水平，采用Pearson相关性分析miR-26a、TLR2、TLR4表达与PV疾病活动(PASI评分和CRP水平)的关系。结果:观察组不同分级PV患者间性别、年龄、体重指数(BMI)及病程资料差异无统计学意义(n P>0.05)；观察组PBMCs中miR-26a、TLR2和TLR4 mRNA表达水平明显高于对照组(n P<0.05)；重度组PV患者PASI评分、CRP水平及miR-26a、TLR2、TLR4 mRNA表达水平明显高于轻度组和中度组(n P<0.05)，中度组PASI评分、CRP水平及miR-26a、TLR2、TLR4 mRNA表达水平明显高于轻度组(n P<0.05)；PV患者PASI评分、CRP水平与miR-26a、TLR2、TLR4 mRNA表达水平均呈正相关(n P0.05); the mRNA expression levels of miR-26a, TLR2 and TLR4 in PBMCs of the study group were significantly higher than those of the control group (n P<0.05); the PASI score, serum CRP level, miR-26a, TLR2 and TLR4 mRNA expression levels in severe PV group were significantly higher than those in mild group and moderate group (n P<0.05), and the above indexe in the moderate group were significantly higher than those in mild group (n P<0.05); the PASI score and serum CRP level of PV patients were positively correlated with miR-26a, TLR2 and TLR4 mRNA expression levels (n P<0.01).n Conclusions:The mRNA expression levels of miR-26a, TLR2 and TLR4 in PBMCs of PV patients are increased and positively correlated with PASI score and CRP level, which can reflect the activity of PV disease.