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目的探讨血液灌流联合血液透析治疗尿毒症的疗效,并与单纯血液透析的效果进行比较。方法将119例患者随机分为联合组和对照组,联合组行血液灌流及血液透析,对照组行常规血液透析,治疗前后观察β2-微球蛋白、甲状旁腺激素(PTH)、尿素氮(Bun)、肌酐(Cr)、血红蛋白(Hb)等指标及临床症状。结果联合组患者的临床症状减轻及PTH清除率显著高于对照组,经统计学分析差异有统计学意义(P<0.05)。结论血液灌流联合血液透析治疗能有效清除尿毒症患者体内的PTH等中分子物质,减轻患者的临床症状,改善患者的生活质量,弥补单纯血液透析的缺点,具有较好的临床应用价值。
Objective To investigate the therapeutic effect of hemoperfusion combined with hemodialysis on uremia and to compare the effect of hemodialysis alone. Methods 119 patients were randomly divided into combined group and control group. The combined group was subjected to hemoperfusion and hemodialysis. The control group was given routine hemodialysis. Β2-microglobulin, parathyroid hormone (PTH) and urea nitrogen Bun), creatinine (Cr), hemoglobin (Hb) and other indicators and clinical symptoms. Results The clinical symptoms and PTH clearance in the combined group were significantly higher than those in the control group, and the difference was statistically significant (P <0.05). Conclusion Hemoperfusion combined with hemodialysis can effectively remove the PTH and other molecular substances in patients with uremia, reduce the clinical symptoms and improve the quality of life of patients to make up for the shortcomings of hemodialysis alone, and has good clinical value.