Since the pioneering work of Gutsche on calixarenes, many functionalized calixarenes have been prepared. The full bromination of calixarene by a direct process has been regarded as unavailable. Therefore, a more circuitous route including three steps has been developed. But in the present work p-tetrabromocalixarene, which serves as a potential intermediate to derive functionalized calixarenes, is successfully synthesized with a high yield by an improved direct bromination procedure. The analytical results are in complete accordance with those reported in previous literature. The reason why the conventional methods cannot provide full bromination is discussed. Since the pioneering work of Gutsche on calixarenes, many functionalized calixarenes have been prepared. The full bromination of calixarene by a direct process has been prepared as unavailable. Therefore, a more circuitous route including three steps has been developed. But in the present work p -tetrabromocalixarene, which serves as a potential intermediate to derive functionalized calixarenes, is successfully synthesized with a high yield by an improved direct bromination procedure. The analysis results are in complete accordance with those reported in previous literature. The reason why the conventional methods can not provide full bromination is discussed.