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目的 动态观察急性脑梗死患者(acutecerebralinfarction,ACI)血浆中S 100蛋白(s 100pro tein,S 100)、髓鞘碱性蛋白(myelinbasicprotein,MBP)的变化,探讨其与脑梗死体积、神经功能缺损程度及梗死部位等方面的相关性。方法 该实验采用酶联免疫吸附法(eyzyme linkedimmunosorbentassay,ELISA)对50例ACI患者的血浆S 100、MBP水平进行动态检测,并与30例对照组患者进行比较,同时应用NIHSS进行神经功能缺损评分及CT扫描测定梗死体积。结果 ACI患者S 100、MBP浓度在发病早期明显升高,S 1001～3d达到峰值,MBP5～7d达到峰值,有严重神经功能缺损的患者S 100、MBP升高更明显,S 100>1.0μg/L、MBP>8.0μg/L、NIHSS>12分,均提示患者预后不良;S 100、MBP的血浆浓度与梗死体积呈显著正相关(r≥0.480,P<0.01),与神经功能缺损程度也呈显著正相关(r≥0.443,P<0.01)。结论 缺血性脑损伤后血浆中S 100、MBP的出现分别与神经胶质细胞、髓鞘受损有关,并通过受损的血脑屏障进入血液,S 100、MBP可作为缺血性脑损伤尤其是大面积脑梗死早期的外周标志物,是比CT更为敏感的指标,对指导治疗有帮助。
Objective To observe the changes of s 100pro tein (S 100) and myelin basic protein (MBP) in the plasma of patients with acute cerebral infarction (ACI), and to investigate their relationship with the volume of cerebral infarction, the degree of neurological deficits And infarction and other aspects of the correlation. Methods The levels of S 100 and MBP in plasma of 50 patients with ACI were measured by enzyme-linked immunosorbentassay (ELISA) in 30 patients. The NIHSS score was used to evaluate the neurological deficits CT scan to measure infarct volume. Results The levels of S 100 and MBP in patients with ACI were significantly higher in the early stage of disease, with the peak value of S 1001 ~ 3d and the peak value of MBP 5 ~ 7d. The S 100 and MBP increased significantly in patients with severe neurological deficit. The S 100> 1.0μg / L, MBP> 8.0μg / L, NIHSS> 12 points, all showed poor prognosis. The plasma concentrations of S 100 and MBP were positively correlated with infarct volume (r≥0.480, P <0.01) There was a significant positive correlation (r≥0.443, P <0.01). Conclusion The occurrence of S 100 and MBP in the plasma after ischemic brain injury are related to the damage of glial cells and myelin, respectively, and enter the blood through the damaged blood-brain barrier. S 100 and MBP can be used as ischemic brain injury In particular, early peripheral cerebral infarction large area markers, is more sensitive than CT indicators, to guide the treatment of help.