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目的探讨联合检测血浆D-二聚体和FDP水平在弥散性血管内凝血(DIC)早期诊断中的临床意义。方法选取早期DIC患者32例,DIC疑诊组15例,正常人(对照组)30例,检测D-二聚体含量和FDP含量。结果 DIC组D-二聚体和FDP水平均明显高于疑诊组及对照组,差异有统计学意义(P<0.01)。疑诊组与对照组比较,D-二聚体差异有统计学意义(P<0.01),而FDP差异无统计学意义(P>0.05)。结论 D-二聚体和FDP的联合检测对DIC的早期诊断具有重要的临床意义。D-二聚体具有更高的特异性,联合检测FDP能提高DIC诊断的灵敏度和特异度。
Objective To investigate the clinical significance of combined detection of plasma D-dimer and FDP levels in the early diagnosis of disseminated intravascular coagulation (DIC). Methods 32 cases of early DIC, 15 cases of DIC suspected and 30 cases of normal (control group) were selected to detect D-dimer content and FDP content. Results DIC group D-dimer and FDP levels were significantly higher than the suspected group and the control group, the difference was statistically significant (P <0.01). There was a significant difference in D-dimer between the suspected and control groups (P <0.01), but there was no significant difference in FDP between the two groups (P> 0.05). Conclusion The combined detection of D-dimer and FDP has an important clinical significance in the early diagnosis of DIC. D-dimer with higher specificity, joint detection of FDP can improve the sensitivity and specificity of DIC diagnosis.