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本文分析我院22例新生儿深部真菌病的临床病理资料。引起真菌病的菌种有毛霉菌、念珠球菌属、小圆形酵母样菌、曲菌等。以血管炎、管壁坏死、化脓性病变、肉芽肿形成及真菌侵袭部位出血坏死改变为主要病理变化。资料表明,17例可能为原发性,5例继发于其他疾病。并认为胸腺变化符合继发性胸腺萎缩改变,该变化可直接影响患儿免疫功能。本病临床表现复杂,无特异性,提示临床对疑似病例应早期诊断,当血培养阴性时,亦应考虑有本病的可能。
This article analyzes 22 cases of neonatal deep mycosis clinical and pathological data. Mycosis caused by fungi Mucorm, Candida, small round yeast-like bacteria, such as fungus. To vasculitis, wall necrosis, purulent lesions, granuloma formation and fungal invasion of bleeding and necrosis changes as the main pathological changes. Data show that 17 cases may be primary, 5 cases secondary to other diseases. And that changes in the thymus consistent with changes in secondary thymic atrophy, the changes can have a direct impact on children’s immune function. The clinical manifestations of this disease is complex and unspecific, suggesting that clinical suspicion of cases should be early diagnosis, when blood culture negative, should also consider the possibility of the disease.