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用丙型肝炎病毒(HCV)非结构抗原进行的第一代抗-HCV试验往往在急性丙型肝炎患者起病后1～6个月进展为慢性疾病时才检出阳性,而大部分未进展为慢性丙型肝炎患者的抗-HCV仍为阴性.目前的第二代试验系统还包括HCV核心抗原.作者利用一项前瞻性多中心研究中的40例非甲非乙型肝炎患者(IgM抗-HBc和IgM抗-HAV均为阴性)的冷冻血清,对Abbott第二代抗-HCV酶免疫试验(EIA)诊断急性丙型肝炎的敏感性进行了评价.结果表明,29例患者(73%)在入院后
First-generation anti-HCV tests with hepatitis C virus (HCV) nonstructural antigens tend to be positive only 1 to 6 months after onset in patients with acute hepatitis C, whereas most do not progress Anti-HCV is still negative in patients with chronic hepatitis C. The current second-generation test system also includes the HCV core antigen.The authors used a prospective, multicenter study of 40 non-A, non-B hepatitis patients -HBc and IgM were negative), the sensitivity of Abbott second-generation anti-HCV enzyme immunoassay (EIA) in the diagnosis of acute hepatitis C was evaluated.The results showed that in 29 patients (73% After admission