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目的:研究健步走对中老年肥胖人群血脂、脂肪细胞因子的影响及与脂联素基因多态性的关联,确定对运动敏感的分子标记。方法:将92名中老年(50～65岁)单纯型肥胖患者,随机分为实验组(70人)和对照组(22人),实验组根据BMI进行分组,BMI≥25为肥胖组,23≤BMI<25为超重组。通过递增负荷运动试验测定其功能能力F.C.,从而推算靶心率。有氧健步走作为主要方式,运动强度范围为开始的40%～50%F.C.至50%～65%F.C.,有效运动时间分别为40 min/次,运动频率为5次/周,运动周期为3个月。结果:经过3个月训练后肥胖组的变化与总体组相似:总胆固醇、低密度脂蛋白胆固醇显著下降(P<0.01),高密度脂蛋白胆固醇显著升高(P<0.05),脂联素水平显著升高、游离脂肪酸出现显著下降(P<0.01)。超重组的值均未出现统计学差异。TT基因型胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇指标都出现了显著性差异(P<0.05,P<0.05,P<0.01)。TG基因型低密度脂蛋白胆固醇出现显著性差异(P<0.05)。结论:健步走是有效改善中老年肥胖人群血脂含量,提高脂联素水平的有效健身方法;APM-1 T45G基因TT基因型与训练后低密度脂蛋白胆固醇指标独立关联,TT基因型可考虑作为运动降血脂的基因敏感标记。
Objective: To study the effect of walking on blood lipids and adipocytokines in obese middle-aged and obese people and its association with adiponectin gene polymorphism to identify motor-sensitive molecular markers. Methods: A total of 92 middle-aged and elderly (50-65 years old) obese individuals were randomly divided into experimental group (70 persons) and control group (22 persons). The experimental group was divided according to BMI, BMI≥25 was obese group, 23 ≤BMI <25 for overweight group. By increasing the load exercise test to determine its functional capacity F.C., to calculate the target heart rate. Aerobic walking as the main mode of exercise intensity range from the beginning of 40% to 50% FC to 50% to 65% FC, the effective exercise time was 40 min / times, the exercise frequency of 5 times / week, the exercise cycle of 3 Months. Results: The changes of obese group after 3 months of training were similar to those of the general group: total cholesterol, low density lipoprotein cholesterol (P <0.01), high density lipoprotein cholesterol (P <0.05), adiponectin Significantly increased levels of free fatty acids decreased significantly (P <0.01). There was no statistical difference in overweight group. TT genotype cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol indicators were significant differences (P <0.05, P <0.05, P <0.01). TG genotype low density lipoprotein cholesterol significant difference (P <0.05). Conclusion: Walk walking is an effective way to effectively improve blood lipid levels and increase adiponectin levels in obese people. The TT genotype of APM-1 T45G gene is independently associated with LDL cholesterol. TT genotype may be considered as Exercise hypolipidemic gene-sensitive markers.