MuRF1和MAFbx是与骨骼肌蛋白分解代谢关系最为密切的泛素蛋白连接酶,是骨骼肌蛋白质降解的标志。目前,有关运动对骨骼肌蛋白质降解的研究较少,本文就MuRF1和MAFbx的结构、作用,以及运动过程中MuRF1mRNA和MAFbxmRNA表达量的变化进行综述,探讨运动过程中骨骼肌蛋白质的降解。 MuRF1 and MAFbx are ubiquitin ligases that are most closely related to skeletal muscle protein catabolism and are hallmarks of skeletal muscle protein degradation. At present, there are few researches on the degradation of skeletal muscle protein by exercise. In this paper, the changes of MuRF1 and MAFbx in the structure, function and expression of MuRF1mRNA and MAFbxmRNA during exercise are reviewed to discuss the degradation of skeletal muscle protein during exercise.