论文部分内容阅读
概述新一代质子泵抑制剂——泮托拉唑,评价该药在临床的意义,提示泮托拉唑由于结构上的改变,在中性和中度酸性条件下比奥美拉唑更稳定,对其靶点——壁细胞的选择性更强,作用更进一步,注射用泮托拉唑可作为治疗消化性出血溃疡急性出血的有效药物之一。治疗急性脑出血并发应激性溃疡出血的疗效明显优于西咪替丁,应作为应急性溃疡出血的首选治疗药物。治疗幽门螺杆菌(HP)泮托拉唑联合两种抗菌药(阿莫西林克拉雷素或甲硝唑)的三联短程疗法对HP根除效果肯定,不良反应少。患者耐受性好,价廉,值得临床推广。
Overview of a new generation of proton pump inhibitor - pantoprazole, evaluation of the drug in the clinical significance, suggesting that due to structural changes of pantoprazole in neutral and moderate acidic conditions more stable than omeprazole, Its target - parietal cells more selective, further effect, injection of pantoprazole can be used as an effective treatment of acute bleeding peptic ulcer medicine. Treatment of acute cerebral hemorrhage complicated by stress ulcer bleeding was significantly better than cimetidine, should be used as the first choice of treatment of acute ulcer bleeding. Triple therapy with HP pantoprazole combined with two antibacterials (amoxicillin clarithromycin or metronidazole) affirmed the eradication effect of HP with few adverse reactions. Patients are well tolerated, inexpensive, worthy of clinical promotion.