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目的观察纳洛酮联合醒脑静对急性重度酒精中毒的治疗效果。方法收集2014年1月-2015年2月医院确诊的急性重度酒精中毒患者112例的临床资料,按编号将患者随机分对照组和观察组各56例。对照组给予纳洛酮治疗,观察组给予纳洛酮联合醒脑静治疗。治疗后,将2组临床疗效进行对比。结果治疗后观察组清醒时间与症状消失时间均明显短于对照组,平均动脉压显著高于对照组;观察组治疗有效率为96.43%显著高于对照组的64.29%,差异均有统计学意义(P<0.05)。结论纳洛酮联合醒脑静治疗急性重度酒精中毒具有起效快、疗效高、安全高等优势,应值得临床大力推广。
Objective To observe the therapeutic effect of naloxone and xingnaojing on acute severe alcoholism. Methods The clinical data of 112 patients with acute severe alcohol poisoning diagnosed in our hospital from January 2014 to February 2015 were collected. The patients were randomly divided into control group (56 cases) and observation group (56 cases) by number. The control group was treated with naloxone, while the observation group was treated with naloxone combined with xingnaojing. After treatment, the clinical efficacy of the two groups were compared. Results After treatment, the awake time and symptom disappearance time in the observation group were significantly shorter than those in the control group, and mean arterial pressure was significantly higher than that in the control group. The effective rate of the observation group was 96.43%, significantly higher than that of the control group (64.29%), the differences were statistically significant (P <0.05). Conclusion Naloxone combined with xingnaojing in the treatment of acute severe alcoholism has the advantages of rapid onset, high efficacy and high safety, and should be clinically promoted.