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目的评价黄芩苷磷脂复合物原位凝胶经鼻给药的鼻黏膜毒性。方法在体蟾蜍药物对纤毛运动的影响,用溶血实验考察药物对生物膜的作用。结果黄芩苷磷脂复合物原位凝胶对蟾蜍鼻纤毛的运动几乎无影响,纤毛运动时间相对百分率约90.1%,并不产生溶血反应。结论黄芩苷磷脂复合物原位凝胶鼻腔给药无明显毒性,经鼻给药的开发是可行的。
Objective To evaluate nasal mucosal toxicity of nasal administration of baicalin phospholipid complex in situ. Methods In vivo toad drugs on ciliary motion, hemolysis experiments to investigate the role of drugs on the biofilm. Results Baicalin phospholipid complexes in situ gel had little effect on the movement of toad nasal cilia, and the relative percentage of ciliary exercise time was about 90.1%, and did not produce hemolytic reaction. Conclusion Baicalin phospholipid complex in situ gel nasal administration without obvious toxicity, nasal administration is feasible.