重复注射镉金属硫蛋白的肾脏毒性

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本文给大鼠腹腔注射0.3mg Cd/kg的镉金属硫蛋白(Cd-Me),每周一次,连续5周。每次注射后收集24小时尿样后处死2~3只大鼠取血、肝、肾以供检查,为了观察肾损害的后果及可恢复性,一组动物保留观察到第6周,即停止任何处理后1周。 重复注射Cd-Mt可导致屡见于慢性镉盐中毒 In this study, rats were injected intraperitoneally with 0.3 mg Cd / kg cadmium metallothionein (Cd-Me) once a week for 5 consecutive weeks. After each injection 24 hours urine samples were collected and 2 to 3 rats were sacrificed to take blood, liver and kidney for examination. To observe the consequences of kidney damage and recoverability, one group of animals was observed for the first 6 weeks 1 week after any treatment. Repeated injection of Cd-Mt can lead to frequent occurrence of chronic cadmium poisoning
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