二氢奎尼丁为抗心律失常药物,目前国内尚未见其长效制剂的药物动力学研究报道。本文以血药浓度测定方法,对其进行了药物动力学研究,取得了初步结果。 实验方法:受试者为7例心房纤颤患者(无肝、肾、消化道及血液系统并发症),受试前2周未服用过类似药物。一次口服长效二氢奎尼丁300mg。于服药后2、4、6、8、12、24小时各取静脉血2ml,室温存放 Dihydroquinidine as anti-arrhythmic drugs, the current domestic has not yet seen its long-acting formulations of pharmacokinetic studies reported. In this paper, blood concentration determination method, its pharmacokinetic study, and achieved initial results. Experimental Methods: Subjects were 7 patients with atrial fibrillation (no liver, kidney, gastrointestinal, and hematologic complications) who had not taken similar medications two weeks prior to the test. Long-term oral administration of dihydroquinidine 300mg. 2, 4, 6, 8, 12, 24 hours after taking venous blood 2ml, stored at room temperature