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目的:研究吲哚胺2,3-二氧酶在不同宫颈病变组织中表达情况。方法:采用免疫组化染色检测35例正常宫颈组织、36例CIN宫颈组织、34例宫颈癌Ⅰ期宫颈组织、35例宫颈癌Ⅱ期-Ⅳ期宫颈组织中IDO表达。结果:正常宫颈组织中IDO表达呈阴性,在宫颈上皮内瘤变中IDO表达逐渐增高,宫颈癌时IDO表达最高,各组IDO表达情况相比较,差异有统计学意义(x2=73.9834,P=0.0000<0.01)。结论:IDO可作为宫颈癌治疗的新靶点。
Objective: To study the expression of indoleamine 2,3-dioxygenase in different cervical lesions. Methods: Immunohistochemical staining was used to detect the expression of IDO in 35 cases of normal cervical tissue, 36 cases of CIN cervical tissue, 34 cases of cervical cancer stage Ⅰ cervical tissue and 35 cases of cervical cancer stage Ⅱ-Ⅳ cervical tissue. Results: The expression of IDO in normal cervical tissue was negative, and the expression of IDO was gradually increased in cervical intraepithelial neoplasia. The expression of IDO was the highest in cervical cancer. The expression of IDO in each group was significantly different (x2 = 73.9834, P = 0.0000 <0.01). Conclusion: IDO can be used as a new target for treatment of cervical cancer.