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生物活性分子一氧化氮(Nitric Oxide,NO)自发现开始,其广泛而重要的生理和病理学功能日益为人们所认识,与其它生物自由基相一致。作为一种相对稳定的气体自由基,NO对人体有双重的生物学作用。一方面其可以调节人体正常的生理功能,如:血液循环、信息传递、能量代谢及免疫调节等。另一方面,体内NO合成量多或少均会造成对机体的危害。如:低血压休克、细胞损伤或高血压,动脉粥样硬化和缺血等。肝脏作为人体能量代谢的重要器官存在NO合酶(NO synthase,NOS),可以合成并释放NO,其对于肝微循环起重要的调节作用。
Since its discovery, the biologically active molecule nitric oxide (NO) has been widely recognized by its extensive and important physiological and pathological functions, consistent with other biological free radicals. As a relatively stable gas free radical, NO has a dual biological effect on the human body. On the one hand it can regulate the body’s normal physiological functions, such as: blood circulation, information transmission, energy metabolism and immune regulation. On the other hand, the body NO synthesis of more or less will cause harm to the body. Such as: hypotensive shock, cell damage or hypertension, atherosclerosis and ischemia. The liver, as an important organ for energy metabolism, has NO synthase (NOS) that synthesizes and releases NO, which plays an important regulatory role in hepatic microcirculation.