论文部分内容阅读
目的:探讨结直肠癌及癌旁组织中i ASPP的表达及其临床意义。方法:采用免疫组化法检测i ASPP在55例结直肠癌组织及47例癌旁组织中的表达情况,分析i ASPP表达与肿瘤浸润深度、分化程度、淋巴结转移的相互关系。结果:1结直肠癌组织中i ASPP的阳性表达率高于癌旁组织(P<0.01);2在高、中和低分化结直肠癌组织中i ASPP阳性表达与肿瘤细胞的分化程度有关(P<0.01);3在T1~T4期结肠直癌中,i ASPP阳性表达与肿瘤浸润深度有关(P<0.01);4结直肠癌组织中i ASPP的表达与淋巴结是否转移有关(P<0.01)。结论:结直肠癌组织中i ASPP的阳性表达率高于癌旁结肠组织,且其表达与肿瘤的分化、肿瘤浸润深度及淋巴结是否转移有关,可能为结直肠恶性肿瘤的诊断提供帮助。
Objective: To investigate the expression of i ASPP in colorectal cancer and its adjacent tissues and its clinical significance. Methods: Immunohistochemistry was used to detect the expression of i ASPP in 55 cases of colorectal cancer tissues and 47 cases of adjacent tissues. The relationship between i ASPP expression and the depth of tumor invasion, differentiation and lymph node metastasis were analyzed. Results: 1 The positive expression rate of i ASPP in colorectal cancer tissues was higher than that in adjacent non-cancerous tissues (P <0.01). 2 The positive expression of i ASPP in high, moderate and poorly differentiated colorectal cancer tissues was related to the differentiation of tumor cells (P <0.01). 3 The positive expression of i ASPP in T1 ~ T4 colorectal cancer was related to the depth of tumor invasion (P <0.01). 4 The expression of i ASPP in colorectal cancer was related to lymph node metastasis ). CONCLUSION: The positive rate of i ASPP in colorectal cancer tissues is higher than that in adjacent normal colon tissues. The expression of i ASPP is correlated with the differentiation of tumor, the depth of tumor invasion and the metastasis of lymph nodes, which may be helpful for the diagnosis of colorectal malignant tumors.