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目的观察胰岛素联合辛伐他汀(SMT)对2型糖尿病患者血清C反应蛋白和脂联素水平的影响。方法 69例T2DM患者随机分为Ins组和Ins+SMT组,分别给予胰岛素及胰岛素联合辛伐他汀,疗程共12周。分别检测两组患者治疗前后FBG、脂联素以及C反应蛋白水平,观察胰岛素联合辛伐他汀对T2DM患者血浆脂联素和C反应蛋白的影响。结果两组患者治疗后血糖均控制良好,Ins+SMT组血浆脂联素水平较Ins组明显升高(P<0.05),而C反应蛋白较对照组明显下降(P<0.05)。结论胰岛素联合辛伐他汀不仅可良好控制T2DM患者血糖,同时还可提高患者血清脂联素水平,降低C反应蛋白,可在一定程度上降低T2DM患者并发动脉粥样硬化的危险性。
Objective To observe the effects of insulin and simvastatin (SMT) on serum C-reactive protein and adiponectin in type 2 diabetic patients. Methods Sixty-nine patients with T2DM were randomly divided into Ins group and Ins + SMT group. Insulin and insulin combined with simvastatin were given respectively for 12 weeks. The levels of FBG, adiponectin and C-reactive protein were measured before and after treatment in two groups. The effects of insulin and simvastatin on plasma adiponectin and C-reactive protein in T2DM patients were observed. Results The blood glucose level was well controlled after treatment in both groups. The level of plasma adiponectin in Ins + SMT group was significantly higher than that in Ins group (P <0.05), and C-reactive protein was significantly lower than that in control group (P <0.05). Conclusion Insulin combined with simvastatin can not only control the blood sugar of T2DM patients, but also increase the level of serum adiponectin and decrease the level of C-reactive protein in T2DM patients, which may reduce the risk of concurrent atherosclerosis in T2DM patients to a certain extent.