[目的]观察芬太尼透皮(商品名:多瑞吉)贴剂治疗晚期消化系统癌痛患者的镇痛效果及对生活质量的影响。[方法]选择中、重度癌痛患者28例使用芬太尼透皮贴剂,每张(贴)2.5 mg(每小时释放芬太尼25μg),72 h更换1次,1周为1个疗程,评估记录治疗前后疼痛强度的变化、不良反应及生活质量的评分比较。[结果]全部病例均获得缓解。明显缓解和完全缓解者26例(92.9%)、轻度缓解2例。不良反应有恶心、呕吐、头昏、嗜睡、便秘,但发生率较低。治疗后除生活自理能力外,其他5项主要指标均较治疗前明显改善(P<0.05)。[结论]芬太尼透皮贴剂治疗晚期消化系统中、重度癌痛,镇痛效果可靠,安全,不良反应少,且使用方便,能明显改善患者生活质量。 [Objective] To observe the analgesic effect of fentanyl transdermal (trade name: Dorothy) patch on patients with advanced digestive system cancer pain and its influence on quality of life. [Methods] Twenty-eight patients with moderate to severe cancer pain were treated with fentanyl transdermal patch, 2.5 mg per tablet (25 μg fentanyl per hour), once every 72 hours and 1 week as a course of treatment , The assessment records before and after treatment pain intensity changes, adverse reactions and quality of life score comparison. [Results] All cases were relieved. Twenty-six patients (92.9%) were relieved and completely relieved, and two patients relieved slightly. Adverse reactions are nausea, vomiting, dizziness, drowsiness, constipation, but the incidence is low. After treatment, except for living self-care ability, the other five main indexes were significantly improved compared with those before treatment (P <0.05). [Conclusion] Fentanyl transdermal patch can treat patients with advanced digestive system with severe cancer pain. The analgesic effect is reliable, safe and with few adverse reactions. It is easy to use and can significantly improve the quality of life of patients.