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目的:通过观察EGFR、NF-κB蛋白表达与鼻咽癌放射敏感性的关系,评价两因子在预测鼻咽癌放射敏感性方面的作用,并为以后靶向基因治疗鼻咽癌、提高放疗效果提供理论依据。方法:采用免疫组织化学SP法检测41例鼻咽癌组织中EGFR及NF-κB的表达情况,并通过随访及临床观察,判断每例患者放疗效果,从而将所有患者分为完全缓解组、部分缓解/稳定组和进展组,评定两因子表达水平与放射敏感性的关系。结果:EG-FR、NF-κB在鼻咽癌中均有不同程度表达,两者在鼻咽癌组织的不同放射敏感性中表达各具有差异性(P<0.05)。完全缓解组与部分缓解/稳定组的EGFR、NF-κB表达均低于进展组(P<0.05),而完全缓解组与部分缓解/稳定组比较差异无统计学意义(P>0.05)。两因子表达与鼻咽癌放射敏感性呈负相关。结论:EGFR、NF-κB可能成为预测鼻咽癌放射敏感性的2个重要指标,为鼻咽癌患者的靶向基因治疗提供理论依据。
OBJECTIVE: To evaluate the role of two factors in predicting nasopharyngeal carcinoma radiosensitivity by observing the relationship between the expression of EGFR and NF-κB and radiosensitivity of nasopharyngeal carcinoma, and to further target the gene therapy for nasopharyngeal carcinoma and improve the radiotherapy effect Provide a theoretical basis. Methods: Immunohistochemical SP method was used to detect the expression of EGFR and NF-κB in 41 cases of nasopharyngeal carcinoma. The follow-up and clinical observation were performed to determine the radiotherapy effect in each case. All the patients were divided into complete remission group, Relieving / stabilizing and progression groups were performed to assess the relationship between the two-factor expression level and radiosensitivity. Results: The expression of EG-FR and NF-κB in nasopharyngeal carcinoma were all different, both of which were different in different radiosensitivity of nasopharyngeal carcinoma (P <0.05). The expression of EGFR and NF-κB in complete remission group and partial remission / stable group were lower than those in progression group (P <0.05), but there was no significant difference between complete remission group and partial remission / stabilization group (P> 0.05). Two-factor expression was negatively correlated with radiosensitivity of NPC. Conclusion: EGFR and NF-κB may be two important indexes for predicting radiosensitivity of nasopharyngeal carcinoma and provide a theoretical basis for targeted gene therapy in patients with nasopharyngeal carcinoma.