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目的:系统评价苍附导痰汤加减联合克罗米芬(CC)治疗多囊卵巢综合征(PCOS)的临床疗效,为临床用药提供依据。方法:计算机检索Pub Med、EMbase、MEDLINE、The Cochrane Library、CBM、CNKI、维普和万方数据库中运用苍附导痰汤加减联合CC治疗PCOS的随机对照试验(RCT),按照纳入与排除标准由两位研究者独立筛选和提取资料,采用Cochrane协作网随机对照试验的质量评价标准评价纳入文献质量,采用Rev Man 5.3软件进行Meta分析。结果:共纳入文献9篇,患者640例。Meta分析结果显示:苍附导痰汤加减联合CC组的临床有效率明显优于单纯CC治疗组[OR=3.72,95%Cl(2.31,5.99)],差异有统计学意义(P<0.00001);苍附导痰汤加减联合CC组的排卵率优于单纯CC治疗组[OR=1.77,95%Cl(1.04,3.01)],差异有统计学意义(P=0.04)。结论:苍附导痰汤加减联合CC治疗PCOS能够提高临床有效率和排卵率。
OBJECTIVE: To systematically evaluate the clinical efficacy of Canshuatantan Decoction combined with clomiphene citrate (CC) in the treatment of polycystic ovary syndrome (PCOS) and provide evidence for clinical use. Methods: Randomized controlled trials (RCTs) were conducted in PubMed, EMbase, MEDLINE, The Cochrane Library, CBM, CNKI, VIP and Wanfang database using Cansifutan Decoction combined with CC in the treatment of PCOS. According to inclusion and exclusion criteria Two investigators independently screened and extracted data, evaluated inclusion quality using the Cochrane Collaboration, a randomized controlled trial of quality evaluation criteria, and performed a meta-analysis using Rev Man 5.3 software. Results: A total of 9 articles were included and 640 patients were included. The results of Meta analysis showed that the clinical effective rate of Cailin Dantan Decoction combined with CC group was significantly better than that of CC group [OR = 3.72,95% Cl (2.31, 5.99)], the difference was statistically significant (P <0.00001) ; Ovulation rate of Cailin Dantan Decoction combined with CC group was better than that of CC group [OR = 1.77,95% Cl (1.04,3.01)], the difference was statistically significant (P = 0.04). Conclusion: Cailin Dantan Decoction combined with CC in the treatment of PCOS can improve the clinical efficiency and ovulation rate.