论文部分内容阅读
目的探讨阿司匹林预防长期性中心静脉导管功能不良的效果，并对比分析。方法将51例采用长期中心静脉导管的血透患者随机分为对照组（A组），阿司匹林组（B组）。在用常规肝素封管基础上，B组服用阿司匹林100mg/d。观察6个月后的导管功能情况、应用尿激酶干预情况、凝血指标的变化、药物副作用。结果50例患者完成研究，导管功能不良发生率分别为3.79%、1.45%（P＜0.05）：各组发生导管功能不良后用尿激酶封管，尿激酶首次干预时间 A、B组分别为（30±21.1） d、（68±45.7）d（P＜0.05）：治疗组的尿激酶干预次数减少（P＜0.05）；治疗组比对照组的PT和APTT延长（P＜0.05）；治疗组无严重副作用发生。结论阿司匹林对于预防长期性中心静脉导管功能不良有一定疗效。“,”Objective To investigate the clinical ef ect of Aspirin in preventing late malfunction in tunneled cuf ed hemodialysis catheters. Methods 51 hemodialysis patients with tunneled cuf ed hemodialysis catheters were randomly assigned to receive placebo(A group) or aspirin 100mg per day(B group). The catheter function, use of Urokinase, blood clot ing index and mdidcine sied-ef ect in two groups were compared afters 6 months fol owed investigation. Results 50 patients fulfil ed the sutdy. The incidence rate of the catheter malfunction respectively was 3.79%、1.45%(P<0.05) . The days of first intervention with the urokinase was(30±21.1)d、(68±45.7)d respectively (P<0.05) . There were singificant dif ference in the control group and therapeutic group (P<0.05) in PT and APTT. There was no significant medicine side-ef ect. Conclusion The Aspirin could prevent the late malfunctin in tunneled cuf ed hemodialysis catheters.